https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Achieving diversity: pathways may be the solution! https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16987 Wed 11 Apr 2018 16:39:10 AEST ]]> A pathway from school to university - reaching down to build up https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11605 Wed 11 Apr 2018 13:49:41 AEST ]]> Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52178 Wed 04 Oct 2023 11:05:28 AEDT ]]> Indigenous VET to Higher Education pathways and transitions: A literature review https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39415 Tue 14 Jun 2022 15:52:20 AEST ]]> Internationalisation pathways of small Singaporean family firms: a socio-cultural perspective https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33186 Tue 11 Sep 2018 12:15:39 AEST ]]> Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46138 Tue 04 Apr 2023 18:59:19 AEST ]]> Transcriptomics of biopsies identifies novel genes and pathways linked to neutrophilic inflammation in severe asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48843 ±2) including genes associated with innate immunity response, neutrophil degranulation and IL-10 signalling. NA presented enrichment to pathways previously linked to neutrophilic inflammation; dendritic cell maturation, Th1, TREM1, inflammasome, Th17 and p38 MAPK, as well as novel links to neuroinflammation, NFAT and PKCθ signalling. EA presented similar transcriptomic profiles to PGA and HC. Despite the higher proportion of bacterial colonization in NA, no changes were observed in the transcriptomic profiles of severe asthma culture positive compared with severe asthma culture negative. Conclusions & Clinical Relevance: NA features a distinct transcriptomic profile with seven pathways enriched in NA compared to EA, PGA and HC. All those with severe asthma had significant enrichment for SUMOylation, basal cell carcinoma signalling and Wnt/β-catenin pathways compared to HC, despite high-dose inhaled corticosteroids. These findings contribute to the understanding of mechanistic pathways in endobronchial biopsies associated with NA and identify potential novel treatment targets for severe asthma.]]> Thu 13 Apr 2023 09:45:44 AEST ]]> A review of natural therapies potentially relevant in triple negative breast cancer aimed at targeting cancer cell vulnerabilities https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38357 Thu 09 Sep 2021 12:21:31 AEST ]]> Contemporary developments in marketing channel literature and the implications for the determinants of international student choice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32720 Mon 23 Sep 2019 12:12:58 AEST ]]> Implementation and scale-up of school-based physical activity interventions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41565 Fri 05 Aug 2022 14:31:09 AEST ]]>